Investigating the chemokine receptor 4 as potential theranostic target in adrenocortical cancer patients
C Bluemel, S Hahner, B Heinze… - Clinical nuclear …, 2017 - journals.lww.com
Purpose Adrenocortical carcinoma (ACC) is a rare but aggressive endocrine tumor with
limited treatment options. Preclinical studies confirmed overexpression of the chemokine
receptor 4 (CXCR4) in this cancer type. This study aimed to analyze the role of CXCR4
imaging using 68 Ga-pentixafor for ACC staging and selection of patients for CXCR4-
directed endoradiotherapy. Methods Thirty patients with histologically proven advanced,
metastasized ACC underwent 18 F-FDG PET/CT and 68 Ga-pentixafor PET/CT within a time …
limited treatment options. Preclinical studies confirmed overexpression of the chemokine
receptor 4 (CXCR4) in this cancer type. This study aimed to analyze the role of CXCR4
imaging using 68 Ga-pentixafor for ACC staging and selection of patients for CXCR4-
directed endoradiotherapy. Methods Thirty patients with histologically proven advanced,
metastasized ACC underwent 18 F-FDG PET/CT and 68 Ga-pentixafor PET/CT within a time …
